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The 2019-new Coronavirus Epidemic: Evidence for Virus Evolution
There is a worldwide concern about the new coronavirus 2019-nCoV as a global public health threat. In this article, we provide a preliminary evolutionary and molecular epidemiological analysis of this new virus. A phylogenetic ... -
Ad hoc laboratory-based surveillance of SARS-CoV-2 by real-time RT-PCR using minipools of RNA prepared from routine respiratory samples
(2020-04-22)Background: A novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in China in late 2019 and subsequently caused a pandemic. Surveillance is important to better appreciate this evolving ... -
Angiotensin‐converting enzyme‐2 (ACE2 ), SARS‐CoV ‐2 and pathophysiology of coronavirus disease 2019 (COVID ‐19)
(2020-05-17)[Abstract]. Angiotensin‐converting enzyme‐2 (ACE2) has been established as the functional host receptor for severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), the virus responsible for the current devastating ... -
Antibody Responses to SARS-CoV-2 in Patients With Novel Coronavirus Disease 2019
(2020-05-28)Background: The novel coronavirus SARS-CoV-2 is a newly emerging virus. The antibody response in infected patients remains largely unknown, and the clinical value of antibody testing has not been fully demonstrated. Methods: ... -
Antimicrobial mouthwashes (gargling) and nasal sprays administered to patients with suspected or confirmed COVID‐19 infection to improve patient outcomes and to protect healthcare workers treating them
(2020)Background: COVID‐19 infection poses a serious risk to patients and – due to its contagious nature – to those healthcare workers (HCWs) treating them. If the mouth and nose of patients with infection are irrigated with ... -
Antiviral mouthwashes: possible benefit for COVID-19 with evidence-based approach
(2020)Background: The outbreak, and pandemic of COVID-19 causing widespread concerns in all health systems of countries. Virus-carrying aerosols can penetrate the healthy human body and lungs, resulting in rapid transmission. ... -
Aptamers, the bivalent agents as probes and therapies for coronavirus infections: A systematic review
(2020-10)Abstract The recently known coronavirus, SARS-CoV-2, has turn into the greatest global health challenge, affecting a large number of societies. The lack of specific treatment and gold-standard diagnostic system has made ... -
The association between COVID‐19 and asthma: A systematic review and meta‐analysis
(2020-09-15)To the Editor, Recently, the associations between COVID‐19 and its comorbidities including hypertension, diabetes, obesity, cardiovascular disease, chronic obstructive pulmonary disease, chronic kidney disease, immunosuppression ... -
Bounding the Predictive Values of COVID-19 Antibody Tests
(2020-05-17)COVID-19 antibody tests have imperfect accuracy. There has been lack of clarity on the meaning of reported rates of false positives and false negatives. For risk assessment and clinical decision making, the rates of interest ... -
Can symptoms of anosmia and dysgeusia be diagnostic for COVID‐19?
(2020-11-20)Objective: Olfactory and taste dysfunction (OTD) is a potential neurological manifestation of coronavirus-2019 (COVID-19). We aimed to investigate the diagnostic value of symptoms of anosmia and dysgeusia for COVID-19. Methods: ... -
Can symptoms of anosmia and dysgeusia be diagnostic for COVID‐19?
(2020-11)Objective: Olfactory and taste dysfunction (OTD) is a potential neurological manifestation of coronavirus-2019 (COVID-19). We aimed to investigate the diagnostic value of symptoms of anosmia and dysgeusia for COVID-19. Methods: ... -
Cardiovascular Considerations for Patients, Health Care Workers, and Health Systems During the Coronavirus Disease 2019 (COVID-19) Pandemic
(2020-03-19)The coronavirus disease-2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 that has significant implications for the cardiovascular care of patients. First, those with COVID-19 ... -
Characterisation of clinical, laboratory and imaging factors related to mild vs. severe covid-19 infection: a systematic review and meta-analysis
(2020-08)Background: Early detection of disease progression associated with severe COVID-19, and access to proper medical care lowers fatality rates of severe cases. Currently, no studies had systematically examined the variables ... -
Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding
(2020-03-13)We report epidemiological and clinical investigations on ten pediatric SARS-CoV-2 infection cases confirmed by real-time reverse transcription PCR assay of SARS-CoV-2 RNA. Symptoms in these cases were nonspecific and no ... -
Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV
(2020-03-27)Since 2002, beta coronaviruses (CoV) have caused three zoonotic outbreaks, SARS-CoV in 2002–2003, MERS-CoV in 2012, and the newly emerged SARS-CoV-2 in late 2019. However, little is currently known about the biology of ... -
Children account for a small proportion of diagnoses of SARS-CoV-2 5 infection and do not exhibit greater viral loads than adults
(2020-03)[Methods] We analyzed the number of SARS-CoV-2 RNA tests of respiratory samples sent to our 32 laboratory between end of February and mid-March 2020. Clinical symptoms and mortality rate were analyzed among SARS-CoV-2-positive ... -
Children with Coronavirus Disease 2019 (COVID‐19): A Review of Demographic, Clinical, Laboratory and Imaging Features in 2,597 Pediatric Patients
(2020-05-17)An epidemic of coronavirus disease 2019 (COVID‐19) has been spreading worldwide. With the rapid increase in the number of infections, children with COVID‐19 appear to be rising. Most research findings regarding adult cases, ... -
Clinical Characteristics of Asymptomatic and Symptomatic Pediatric Coronavirus Disease 2019 (COVID-19): A Systematic Review
(2020-09)Background and objectives: Characterization of pediatric coronavirus disease 2019 (COVID-19) is necessary to control the pandemic, as asymptomatic or mildly infected children may act as carriers. To date, there are limited ... -
Clinical diagnostic value of CT imaging in COVID-19 with multiple negative RT-PCR testing
(2020-03-13)Dear Editor, At the end of December 2019, an outbreak of unexplained pneumonia in Wuhan [1,2] was caused by Severe Acute Respiratory Syndrome Coronavirus −2 (SARS-CoV-2) infection named Coronavirus Disease-19 (COVID-19). ... -
Clinical Performance of SARS-CoV-2 Molecular Testing
(2020-05-08)Molecular testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the gold standard for diagnosis of coronavirus disease 2019 (COVID-19), but the test clinical performance is poorly understood. From ...