dc.contributor.author | Miller, B R | |
dc.contributor.author | Mitchell, C J | |
dc.date.accessioned | 2023-01-13T16:15:43Z | |
dc.date.available | 2023-01-13T16:15:43Z | |
dc.date.issued | 2014 | |
dc.identifier.uri | https://pubmed.ncbi.nlm.nih.gov/1659238/ | en_US |
dc.identifier.uri | https://hdl.handle.net/20.500.12663/3359 | |
dc.description.abstract | Two inbred (isofemale) Aedes aegypti mosquito lines were derived that manifested a resistant or susceptible phenotype following ingestion of yellow fever virus; lack of virus movement from the midgut defined the resistant phenotype. Other flaviviruses, including dengue 1-4, Uganda S, and Zika, viruses behaved in a similar fashion in the two mosquito lines. Crosses between the two lines produced progeny that were of intermediate susceptibility, indicating codominance; F2 backcrosses to the parents yielded results consistent with a major controlling genetic locus and provide evidence of a second locus capable of modulating the phenotype of the major gene. The rapid selection necessary to fix the susceptible and refractory phenotypes support the hypothesis of a single major controlling locus. Viral movement across the midgut is likely to be governed by a single major gene and modifying minor genes or a group of closely linked genes. These inbred mosquito lines will be useful in discovering the molecular basis for flavivirus resistance in Ae. aegypti. | en_US |
dc.language | English | en_US |
dc.subject | Zika Research Project | en_US |
dc.subject | Zika Virus | en_US |
dc.subject | Flavivirus | en_US |
dc.subject | Yellow Fever | en_US |
dc.subject | Aedes Aegypti | en_US |
dc.title | Genetic selection of a flavivirus-refractory strain of the yellow fever mosquito Aedes aegypti | en_US |
eihealth.country | Others | en_US |
eihealth.category | Epidemiology and epidemiological studies | en_US |
eihealth.type | Research protocol information | en_US |
eihealth.maincategory | Save Lives / Salvar Vidas | en_US |
dc.relation.ispartofjournal | American Journal of Tropical Medicine and Hygiene | en_US |