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dc.contributor.authorUtarini, Adi
dc.contributor.authorAhmad, Riris A
dc.contributor.authorIndriani, Citra
dc.description.abstractThis cluster randomised trial will evaluate the efficacy of Wolbachia-infected Aedes aegytpi mosquitoes in reducing dengue cases in Yogyakarta City, Indonesia. Primary objective: To assess the efficacy of community-based deployments of Wolbachia-infected Aedes aegypti mosquitoes in reducing the incidence of symptomatic, virologically-confirmed dengue cases of any severity in Yogyakarta residents aged 3-45 years in release areas, relative to non-release areas. Secondary objectives: To measure the efficacy of the Wolbachia method against each of the four DENV serotypes; to measure the efficacy of the Wolbachia method in reducing the incidence of symptomatic virologically confirmed Zika virus and chikungunya virus infection in release areas, relative to non-release areas; to quantify the level of human mobility within Yogyakarta City, and estimate the proportion of residents' exposure time that they spend outside the treatment arm to which they were randomised; and to determine whether community-based deployment of Wolbachia-infected Ae. aegypti mosquitoes reduces the abundance of wild-type Ae. aegypti adults, or alternatively, alters the abundance of adults from Aedes species other than Ae. aegypti (e.g. Ae. albopictus)en_US
dc.subjectZika Research Projecten_US
dc.subjectAedes aegyptien_US
dc.subjectChikungunya virusen_US
dc.subjectZika Virusen_US
dc.titleApplying Wolbachia to Eliminate Dengue AWEDen_US
eihealth.categoryEpidemiology and epidemiological studiesen_US
eihealth.typeOther publicationsen_US
eihealth.maincategoryProtect Health Care Workers / Proteger la Salud de los Trabajadoresen_US
dc.relation.ispartofjournalClinical Trialsen_US
dc.contributor.corporatenameIndonesia. Faculty of Medicine, Universitas Gadjah Madaen_US
dc.contributor.corporatenameAustralia. Monash Universityen_US
dc.contributor.corporatenameIndonesia. The Tahija Foundationen_US

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