dc.contributor.author | Williams, Nia et al. | |
dc.date.accessioned | 2021-03-16T20:34:33Z | |
dc.date.available | 2021-03-16T20:34:33Z | |
dc.date.issued | 2020-09-10 | |
dc.identifier.uri | https://doi.org/10.1007/s00431-020-03801-6 | en_US |
dc.identifier.uri | https://hdl.handle.net/20.500.12663/2519 | |
dc.description.abstract | Data show that children are less severely affected with SARS-Covid-19 than adults; however, there have been a small proportion of children who have been critically unwell. In this systematic review, we aimed to identify and describe which underlying comorbidities may be associated with severe SARS-CoV-2 disease and death. The study protocol was in keeping with Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. A total of 1726 articles were identified of which 28 studies fulfilled the inclusion criteria. The 28 studies included 5686 participants with confirmed SARS-CoV-2 infection ranging from mild to severe disease. We focused on the 108 patients who suffered from severe/critical illness requiring ventilation, which included 17 deaths. Of the 108 children who were ventilated, the medical history was available for 48 patients. Thirty-six of the 48 patients (75%) had documented comorbidities of which 11/48 (23%) had pre-existing cardiac disease. Of the 17 patients who died, the past medical history was reported in 12 cases. Of those, 8/12 (75%) had comorbidities.
Conclusion: Whilst only a small number of children suffer from COVID-19 disease compared to adults, children with comorbidities, particularly pre-existing cardiac conditions, represent a large proportion of those that became critically unwell. | en_US |
dc.language | English | en_US |
dc.subject | COVID-19 | en_US |
dc.subject | Severe Acute Respiratory Syndrome | en_US |
dc.subject | Betacoronavirus | en_US |
dc.subject | Child | en_US |
dc.subject | Systematic Review | en_US |
dc.subject | Coronavirus Infections | en_US |
dc.subject | Adolescent | en_US |
dc.subject | Comorbidity | en_US |
dc.title | COVID-19 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in children and adolescents: a systematic review of critically unwell children and the association with underlying comorbidities | en_US |
eihealth.country | Others | en_US |
eihealth.category | Clinical characterization and management | en_US |
eihealth.type | Published Article | en_US |
eihealth.maincategory | Slow Spread / Reducir la Dispersión | en_US |
dc.relation.ispartofjournal | Eur J Pediatr | en_US |