dc.contributor.author | Zhu, Lihua et al. | |
dc.date.accessioned | 2020-05-18T16:58:42Z | |
dc.date.available | 2020-05-18T16:58:42Z | |
dc.date.issued | 2020-05-01 | |
dc.identifier.uri | https://doi.org/10.1016/j.cmet.2020.04.021 | en_US |
dc.identifier.uri | https://hdl.handle.net/20.500.12663/1532 | |
dc.description.abstract | Type 2 diabetes (T2D) is a major comorbidity of COVID-19. However, the impact of blood glucose (BG) control on the degree of required medical interventions and on mortality in patients with COVID-19 and T2D remains uncertain. Thus, we performed a retrospective, multi-centered study of 7,337 cases of COVID-19 in Hubei Province, China, among which 952 had pre-existing T2D. We found that subjects with T2D required more medical interventions and had a significantly higher mortality (7.8% versus 2.7%; adjusted hazard ratio [HR], 1.49) and multiple organ injury than the non-diabetic individuals. Further, we found that well-controlled BG (glycemic variability within 3.9 to 10.0 mmol/L) was associated with markedly lower mortality compared to individuals with poorly controlled BG (upper limit of glycemic variability exceeding 10.0 mmol/L) (adjusted HR, 0.14) during hospitalization. These findings provide clinical evidence correlating improved glycemic control with better outcomes in patients with COVID-19 and pre-existing T2D. | en_US |
dc.language | English | en_US |
dc.subject | COVID-19 | en_US |
dc.subject | Coronavirus | en_US |
dc.subject | Infectious Diseases | en_US |
dc.subject | Diabetes Mellitus | en_US |
dc.subject | Blood Glucose | en_US |
dc.subject | Mortality | en_US |
dc.subject | SARS-CoV-2 | en_US |
dc.title | Association of Blood Glucose Control and Outcomes in Patients with COVID-19 and Pre-existing Type 2 Diabetes | en_US |
eihealth.country | Others | en_US |
eihealth.category | Epidemiology and epidemiological studies | en_US |
eihealth.type | Published Article | en_US |
eihealth.maincategory | Save Lives / Salvar Vidas | en_US |
dc.relation.ispartofjournal | Cell Metabolism | en_US |