dc.contributor.author | Zhu, Zhen et al. | |
dc.date.accessioned | 2020-04-16T22:05:27Z | |
dc.date.available | 2020-04-16T22:05:27Z | |
dc.date.issued | 2020-03-30 | |
dc.identifier.uri | https://doi.org/10.1016/j.jinf.2020.03.060 | en_US |
dc.identifier.uri | https://hdl.handle.net/20.500.12663/1061 | |
dc.description.abstract | Lopinavir/ritonavir and arbidol have been previously used to treat acute respiratory syndrome- coron- avirus 2 (SARS-CoV-2) replication in clinical practice; nevertheless, their effectiveness remains controver- sial. In this study, we evaluated the antiviral effects and safety of lopinavir/ritonavir and arbidol in pa- tients with the 2019-nCoV disease (COVID-19). Fifty patients with laboratory-confirmed COVID-19 were divided into two groups: including lopinavir/ritonavir group (34 cases) and arbidol group (16 cases). Lopinavir/ritonavir group received 400 mg/100mg of Lopinavir/ritonavir, twice a day for a week, while the arbidol group was given 0.2 g arbidol, three times a day. Data from these patients were retrospec- tively analyzed. The cycle threshold values of open reading frame 1ab and nucleocapsid genes by RT- PCR assay were monitored during antiviral therapy. None of the patients developed severe pneumonia or ARDS. There was no difference in fever duration between the two groups (P=0.61). On day 14 after the admission, no viral load was detected in arbidol group, but the viral load was found in 15(44.1%) patients treated with lopinavir/ritonavir. Patients in the arbidol group had a shorter duration of positive RNA test compared to those in the lopinavir/ritonavir group (P<0.01). Moreover, no apparent side effects were found in both groups. In conclusion, our data indicate that arbidol monotherapy may be superior to lopinavir/ritonavir in treating COVID-19. | en_US |
dc.language | English | en_US |
dc.subject | COVID-19 | en_US |
dc.subject | Coronavirus | en_US |
dc.subject | Infectious Diseases | en_US |
dc.subject | Lopinavir | en_US |
dc.subject | Ritonavir | en_US |
dc.title | Arbidol monotherapy is superior to lopinavir/ritonavir in treating COVID-19 | en_US |
eihealth.country | Others | en_US |
eihealth.category | Candidate therapeutics RD | en_US |
eihealth.type | Research protocol information | en_US |
eihealth.maincategory | Save Lives / Salvar Vidas | en_US |
dc.relation.ispartofjournal | Journal of Infection | en_US |