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COVID-19 virus may have neuroinvasive potential and cause neurological complications: a perspective review
(2020-05-16)Coronavirus disease 2019 (COVID-19) was reported at the end of 2019 in China for the first time and has rapidly spread throughout the world as a pandemic. Since COVID-19 causes mild to severe acute respiratory syndrome, ... -
COVID-19: A Brief Overview of the Discovery Clinical Trial
(2020-04-10)COVID-19 (coronavirus disease 2019) is a worldwide outbreak of pneumonia and acute respiratory distress syndrome. It is unambiguously linked to the human–human transmission of a novel coronavirus. Mutagenomic analyses ... -
Covid2019 / SARSCoV2 coronavirus antivirals
(2020-04-20)Includes: Interferons, Nucleoside analogs, Protease inhibitors, Furin Convertase Cleavage inhibitors, Reverse transcriptase inhibitors, RNA Polymerase/Synthesis Inhibitors, Neuraminidase inhibitors, Angiotensin II receptor ... -
COVID‐19 treatment by repurposing drugs until the vaccine is in sight
(2020-03-29)Corona virus disease (COVID-19) has created pandemic in the world as declared by WHO on March 12, 2020. It is a viral disease caused by SARS-CoV 2 virus and has affected large populations in over 120 countries. There is ... -
Current Evidence of Interleukin-6 Signaling Inhibitors in Patients With COVID-19: A Systematic Review and Meta-Analysis
(2020-12-15)Background: Interleukin-6 (IL-6) is known to be detrimental in coronavirus disease 2019 (COVID-19) because of its involvement in driving cytokine storm. This systematic review and meta-analysis aimed to assess the safety ... -
Decreased mortality in COVID-19 patients treated with Tocilizumab: a rapid systematic review and meta-analysis of observational studies
(2020-09-23)Background: We systematically reviewed the literature to answer the following research questions: 1) does IL-6 (receptor) antagonist therapy reduce mortality in COVID-19 patients compared to patients not treated with IL-6 ... -
Diagnosis and management of the drug hypersensitivity reactions in Coronavirus disease 19
(2020-06-08)Coronavirus disease 2019 (COVID‐19), a respiratory tract infection caused by a novel human coronavirus, the severe acute respiratory syndrome coronavirus 2, leads to a wide spectrum of clinical manifestations ranging from ... -
Directly Acting Antivirals for COVID-19: Where Do We Stand?
(2020-08-05)The outbreak of a novel coronavirus (SARS-CoV-2) in Wuhan, China in December 2019 has now become a pandemic with no approved therapeutic agent. At the moment, the genomic structure, characteristics, and pathogenic mechanisms ... -
Discovering Drugs to Treat Coronavirus Disease 2019 (COVID-19)
The SARS-CoV-2 virus emerged in December 2019 and then spread rapidly worldwide, particularly to China, Japan, and South Korea. Scientists are endeavoring to find antivirals specific to the virus. Several drugs such as ... -
Do stem cells have a role in the treatment of COVID-19?
(2020-04-13)Stem cells get their name from their ability to divide and then transform into any type of tissue. This means they can ‘procreate’ multiple cells of any type, something other cells cannot do. The treatment with stem cells ... -
Dose prediction for repurposing nitazoxanide in SARS-CoV-2 treatment or chemoprophylaxis
(2020-05-06)Background: Severe acute respiratory syndrome coronavirus 2 (SARS−CoV−2) has been declared a global pandemic by the World Health Organisation and urgent treatment and prevention strategies are needed. Many clinical trials ... -
Doxycycline and Hydroxychloroquine as Treatment for High-Risk COVID-19 Patients: Experience from Case Series of 54 Patients in Long-Term Care Facilities
(2020-05-22)Importance: Patients in long-term care facilities (LTCF) are at a high-risk of contracting COVID-19 due to advanced age and multiple comorbidities. Without effective treatments, outbreaks in such facilities will become ... -
Drug vignettes: Azithromycin
(2020-05-13)Description of the drug, including regulatory status: Azithromycin is a macrolide antibacterial drug, derived from erythromycin, licensed in the USA and in the UK, and used to treat bacterial infections. It has been used ... -
Dysregulation of immune response in patients with COVID-19 in Wuhan, China
(2020-03-12)[Conclusions] Of the 452 patients with COVID-19 recruited, 286 were diagnosed as severe infection. The median age was 58 years and 235 were male. The most common symptoms were fever, shortness of breath, expectoration, ... -
Effect of Colchicine vs Standard Care on Cardiac and Inflammatory Biomarkers and Clinical Outcomes in Patients Hospitalized With Coronavirus Disease 2019
(2020)Importance: Severe acute respiratory syndrome coronavirus 2 infection has evolved into a global pandemic. Low-dose colchicine combines anti-inflammatory action with a favorable safety profile. Objective: To evaluate the ... -
Effect of hydroxychloroquine with or without azithromycin on the mortality of coronavirus disease 2019 (COVID-19) patients: a systematic review and meta-analysis
(2020-08-26)Background: Hydroxychloroquine or chloroquine with or without azithromycin have been widely pro-moted to treat coronavirus disease 2019 (COVID-19) following earlyin vitroantiviral effects against se-vere acute respiratory ... -
The Effect of Metformin Consumption on Mortality in Hospitalized COVID-19 patients: a systematic review and meta-analysis
(2020-11-11)Background and aims: Diabetes is one of the most common comorbidities, and it is associated with poorer outcomes in patients with coronavirus disease 2019 (COVID-19). Preliminary findings showed that mortality was reduced ... -
The effect of quercetin on the prevention or treatment of COVID-19 and other respiratory tract infections in humans: A rapid review
(2020-07-30)Brief overview: There is currently insufficient evidence to recommend quercetin supplementation as a therapy for the treatment or prevention of COVID-19. Three human clinical trials with low risk of bias suggest that oral ... -
Effect of remdesivir on patients with COVID-19: A network meta-analysis of randomized control trials
(2020-10-15)Several randomized controlled trials (RCTs) were conducted to investigate the effect of remdesivir for patients with COVID-19, but their results were conflicting. Thus, we conducted a network meta-analysis comparing the ... -
Effectiveness and Safety of Glucocorticoids to Treat COVID-19: A Rapid Review and Meta-Analysis
(2020-04-22)Background: Glucocorticoids are widely used in the treatment of various pulmonary inflammatory diseases, but they are also often accompanied by significant adverse reactions. Published guidelines point out that low dose ...